Approval of Inrebic, which was previously known as fedratinib, is the first domino to fall in Bristol-Myers bet on Celgene’s product pipeline. 

While Celgene’s top-selling blood cancer drug Revlimid (lenalidomide) was a key draw for Bristol-Myers, the pharma also made a case to skeptical investors that Celgene’s experimental drugs could give it a foundation for the future. 

Among the five drugs highlighted by Bristol-Myers, Wall Street sales estimates for Inrebic are the lowest, ranging between $300 million to $500 million by 2028, according to an activist investor which opposed the Celgene deal. 

Much more important are the multiple sclerosis drug ozanimod and the CAR-T cancer therapies bb2121 and lisocabtagene maraleucel. 

All told, Bristol-Myers expects the five drugs plus one of its own to eventually generate more than $15 billion in annual revenue. 


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